Fig. 3

RNAseq analysis of M2 and M2 VitE:SM nanoemulsion-treated macrophages. a Volcano plot showing differentially expressed genes in VitE:SM nanoemulsions-treated (1 mg/mL) M2 macrophages versus naïve M2 macrophages. Red dots, genes upregulated; blue dots, genes downregulated. Genes of interested have been labelled in black. b Gene set enrichment analysis (GSEA) plots showing a significant enrichment in the indicated gene signatures for VitE:SM nanoemulsions-treated M2 macrophages. Normalized enrichment score (NES) and p- and q- values are indicated for each plot. c Histogram representation of the NES of significantly altered gene signatures down- (blue) and upregulated (red) in VitE:SM-treated M2 macrophages