Fig. 4
Distribution of EVs@UiO-66-NH2@siRNA in the gastrointestinal tract. (A) Distribution of free Cy5.5-siRNA, UiO-66-NH2@Cy5.5-siRNA, and EVs@UiO-66-NH2@Cy5.5-siRNA, in the gastrointestinal tract of mice 24 h following oral administration. (B) Distribution of the three types of nanoparticles in other major organs (heart, liver, spleen, lung, kidney). (C) Quantitative analysis of Cy5.5 fluorescence signals in colon tissues after oral administration of the three types of nanoparticles for 24 h (n = 3). Data are presented as means ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001