Fig. 10

Reshaping of RA immune microenvironment by HA-RM-Cel-BR. (a) Immunofluorescence staining of M1 macrophages (iNOS: red) and M2 macrophages (CD163: green) in ankle joints, scale bar = 20 μm. (b) Immunofluorescence of Treg cells (FOXP3: green) and Th17 cells (IL-17: red) in ankle joints. (c) Immunofluorescence expression of plasma cells (CD138: yellow) in ankle joints. Relative expression levels of iNOS (d), CD163 (e), FOXP3 (f), IL-17 (g), and CD138 (h) in ankle joints. (i) Schematic representation of HA-RM-Cel-BR regulating the joint immune microenvironment. Data are presented as mean ± SD (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001