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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration

Fig. 4

Transcriptome sequencing analysis of regulatory mechanisms of multifunctional nanoplatforms. (A) Volcano plot showing the differential gene expression between the SIRT1/SOX9@TGPNPs group and the LPS group. (B) The heatmap shows the different species of DEGs between the SIRT/SOX9@TGPNPs group and the LPS group. (C) Top 20 of biological process enrichment bar plots. (D) Top 20 of KEGG enrichment analysis. GSEA of FoxO signaling pathway (E) and TGF-β signaling pathway (F). SIRT1/SOX9@GPNPs, GPNPs assembled sequentially with SOX9- expressing plasmid and SIRT1 protein

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Journal of Nanobiotechnology

ISSN: 1477-3155

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