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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration

Fig. 6

Therapeutic efficacy and sustained release of composite hydrogels. (A) Immunofluorescence staining for NLRP3, COL II, and KRT-19 images of frozen sections of hydrogels (n = 3). (B) Quantitative analysis of fluorescence intensity of NLRP3, COL II, and KRT-19. (C) Representative IVIS images of rat disc at 0, 7, and 14 days. The color bar (from black to yellow) indicates the change in fluorescence signal intensity from low to high. Data are presented as mean ± SD. *p < 0.05. ns, no significant difference. Statistical significance was determined by one-way ANOVA with a post-hocTukey test for (B). G-HA, hydrogel formed by crosslinking GelMA and OHA; GPNPs@G-HA, composite hydrogel loaded with GPNPs; SIRT1/SOX9@GPNPs@G-HA, composite hydrogel loaded with SIRT1/SOX9@GPNPs; 2×, composite hydrogel with double concentration of SIRT1/SOX9@GPNPs; 3×, composite hydrogel with triple concentration of SIRT1/SOX9@GPNPs; SIRT1/SOX9@GPNPs-cy3, cy3-labeled SIRT1/SOX9@GPNPs; SIRT1/SOX9@GPNPs-cy3@G-HA, composite hydrogel loaded with cy3-labeled SIRT1/SOX9@GPNPs

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Journal of Nanobiotechnology

ISSN: 1477-3155

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