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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration

Fig. 7

In vivo therapeutic effects of composite hydrogels assessed by imaging and histology. (A) Representative X-Ray images and MRI images of rat tails from the Sham (non-punctured) group, Defect (punctured with PBS injection) group, G-HA (punctured with G-HA injection) group, and SIRT1/SOX9@GPNPs@G-HA (punctured with SIRT1/SOX9@GPNPs@G-HA injection) group, respectively. (B) H&E and SO/FG staining of the IVD after different treatments at post-operation weeks 4 and 8. Disc height index (DHI) (%) (n = 3) (C) and mean gray value (n = 3) (D) of the IVD. (E) Histological grade of sections in different groups at post-operation 4 weeks and 8 weeks (n = 3). Data are presented as mean ± SD. *p < 0.05. ns, no significant difference. Statistical significance was determined by one-way ANOVA with a post-hocTukey test for (C), (D) and (E). G-HA, hydrogel formed by crosslinking GelMA and OHA; GPNPs@G-HA, composite hydrogel loaded with GPNPs; SIRT1/SOX9@GPNPs@G-HA, composite hydrogel loaded with SIRT1/SOX9@GPNPs

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Journal of Nanobiotechnology

ISSN: 1477-3155

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