Fig. 1

SKN inhibits apoptosis of HUVECs and Evol inhibits RAW264.7 lipid influx. (A) Protein-protein interaction network analysis among the 23 potential intersection targets. (B) Cell viability of HUVECs and (C) RAW264.7 cells with SKN and Evol co-treatment. (D) Confocal images and quantitative analysis of TUNEL staining in HUVECs. Scale bar = 50 μm. [Hcy] = 100 µM. (E) Flow cytometry analysis of apoptosis of activated HUVECs (left) with quantitative data (right). [Hcy] = 100 µM. (F) Confocal images and quantitative analysis of Dil-oxLDL in RAW264.7 with different treatment. [Hcy] = 100 µM, [Dil-oxLDL] = 40 µg/mL. Scale bar = 50 μm. (G) images of Oil Red O (ORO)-stained in RAW264.7 cells. [Hcy] = 100 µM, [oxLDL] = 80 µg/mL. Scale bar = 20 μm. Date are mean ± SD (n = 3) **P < 0.01, ***P < 0.001